NELL-1 as a Target Antigen in Asbestosis Associated Membranous Nephropathy - A Case Report. in Indian journal of nephrology / Indian J Nephrol. 2025 Jan-Feb;35(1):103-105. doi: 10.25259/IJN_65_2024. Epub 2024 Jun 4.

2025

Tipo pubblicazione

Case Reports; Journal Article;

Autori/Collaboratori (4)Vedi tutti...

Papou SM
Department of Radiology, Pondicherry Institute of Medical Sciences, Kalathumettupathai, Kalapet, Pondicherry, India.
Ambroise MM
Department of Pathology, Pondicherry Institute of Medical Sciences, Kalathumettupathai, Kalapet, Pondicherry, India.
Pathak N
Department of Nephrology, All India Institute of Medical Sciences (AIIMS), Bathinda, Punjab, India.

et alii...

Abstract

An 80-year-old male with a history of prolonged asbestos exposure presented with 24-hour urine protein of 8 gm, and serum albumin of 1.7 gm/dl. Renal biopsy disclosed features of membranous nephropathy. Immunohistochemistry showed positivity for neural epidermal-like growth factor- like 1 (NELL1) (2+/3+). Further assessment uncovered an incidental finding of asbestos-related pleural plaques and left hemithorax volume loss on computed tomography (CT) chest, leading to a diagnosis of asbestosis. This case highlights the rare association between asbestosis and NELL-1 positive membranous nephropathy.

PMID : 39872277

DOI : 10.25259/IJN_65_2024