Asbestosis.

2024

Tipo pubblicazione

Study Guide; Book Chapter;

Autori/Collaboratori (3)

Bhandari J
Punjab Medical College/University of Health Scienes
Thada PK
Punjab Medical College/University of Health Sciences
Sedhai YR
Virginia Commonwealth Un School of Med

Abstract

Asbestosis is an interstitial lung disease caused by the inhalation of asbestos fibers. These fibers are different mineral silicates (mainly hydrated magnesium silicates) and are classified into two main categories based on their shape, i.e., serpentine and amphibole. Serpentine fibers include chrysolites that are curly and flexible and are less pathogenic than amphibole fibers. Chrysolite being more flexible, curvy, and more soluble settles in the upper part of the respiratory tract. The mucociliary function is more prominent in the upper respiratory tract, so chrysolite fibers are easily removed. Amphiboles (crocidolite, amosite, tremolite, and anthophyllite) are straight, stiff, more brittle fibers. They are more toxic than serpentine fibers as they are less soluble and straight. They usually align with the airstream and reach deeper into the lungs and the interstitium by penetrating the epithelium. Asbestos fibers have been historically chosen for construction, shipping, mining, and aerospace engineering commercial use because of their high electrical and thermal resistance and low cost.

PMID : 32310445

DOI : NBK555985 [bookaccession]