Diffuse Pleural Mesothelioma: Advances in Molecular Pathogenesis, Diagnosis, and Treatment. in Annual review of pathology / Annu Rev Pathol. 2024 Jan 24;19:11-42. doi: 10.1146/annurev-pathol-042420-092719. Epub 2023 Sep 18.

2024

Tipo pubblicazione

Journal Article; Review;

Autori/Collaboratori (7)Elenco ridotto...

Febres-Aldana CA
Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA; email: yangs2@mskcc.org, ladanyim@mskcc.org.
Fanaroff R
Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA; email: yangs2@mskcc.org, ladanyim@mskcc.org.
Offin M
Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Zauderer MG
Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Sauter JL
Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA; email: yangs2@mskcc.org, ladanyim@mskcc.org.
Yang SR
Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA; email: yangs2@mskcc.org, ladanyim@mskcc.org.
Ladanyi M
Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA; email: yangs2@mskcc.org, ladanyim@mskcc.org.

Abstract

Diffuse pleural mesothelioma (DPM) is a highly aggressive malignant neoplasm arising from the mesothelial cells lining the pleural surfaces. While DPM is a well-recognized disease linked to asbestos exposure, recent advances have expanded our understanding of molecular pathogenesis and transformed our clinical practice. This comprehensive review explores the current concepts and emerging trends in DPM, including risk factors, pathobiology, histologic subtyping, and therapeutic management, with an emphasis on a multidisciplinary approach to this complex disease.

PMID : 37722697

DOI : 10.1146/annurev-pathol-042420-092719

Keywords

Humans; Mesothelioma; Risk Factors;