Cause specific mortality in an Italian pool of asbestos workers cohorts. in American journal of industrial medicine / Am J Ind Med. 2024 Jan;67(1):31-43. doi: 10.1002/ajim.23546. Epub 2023 Oct 19.

2024

Tipo pubblicazione

Journal Article;

Autori/Collaboratori (43)Vedi tutti...

Ferrante D
Department of Translational Medicine, Università del Piemonte Orientale and CPO Piemonte, Novara, Italy.
Angelini A
Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy.
Barbiero F
Department of Medical Area (DAME), University of Udine, Udine, Italy.

et alii...

Abstract

BACKGROUND: Asbestos is a known human carcinogen and is causally associated with malignant mesothelioma, lung, larynx and ovarian cancers. METHODS: Cancer risk was studied among a pool of formerly asbestos-exposed workers in Italy. Fifty-two Italian asbestos cohorts (asbestos-cement, rolling-stock, shipbuilding, and other) were pooled and their mortality follow-up was updated to 2018. Standardized mortality ratios (SMRs) were computed for major causes of death considering duration of exposure and time since first exposure (TSFE), using reference rates by region, age and calendar period. RESULTS: The study included 63,502 subjects (57,156 men and 6346 women): 40% who were alive, 58% who died (cause known for 92%), and 2% lost to follow-up. Mortality was increased for all causes (SMR: men.=.1.04, 95% confidence interval [CI] 1.03-1.05; women.=.1.15, 95% CI 1.11-1.18), all malignancies (SMR: men.=.1.21, 95% CI 1.18-1.23; women.=.1.29, 95% CI 1.22-1.37), pleural and peritoneal malignancies (men: SMR.=.10.46, 95% CI 9.86-11.09 and 4.29, 95% CI 3.66-5.00; women: SMR.=.27.13, 95% CI 23.29-31.42 and 7.51, 95% CI 5.52-9.98), lung (SMR: men.=.1.28, 95% CI 1.24-1.32; women.=.1.26, 95% CI 1.02-1.53), and ovarian cancer (SMR.=.1.42, 95% CI 1.08-1.84). Pleural cancer mortality increased during the first 40 years of TSFE (latency), reaching a plateau thereafter. CONCLUSIONS: Analyses by time-dependent variables showed that the risk for pleural neoplasms increased with latency and no longer increases at long TSFE, consistent with with asbestos clearance from the lungs. Peritoneal neoplasm risk increased over all observation time.

PMID : 37855384

DOI : 10.1002/ajim.23546

Keywords

Male; Humans; Female; Cause of Death; Mesothelioma/etiology; Cohort Studies; Occupational Exposure/adverse effects; Occupational Diseases/etiology; Construction Materials; Asbestos/adverse effects; Pleural Neoplasms; Peritoneal Neoplasms; Ovarian Neoplasms; Italy/epidemiology; Lung Neoplasms/etiology;